The utilization of homologous recombination in embryonic stem cells as a means to generate mice carrying pre-determined modifications of genomic sequences has revolutionized the study of developmental biology. Recognizing the potential efficiencies that can be obtained by high-throughput production at centralized technology centers, a number of large-scale efforts for generating mice with targeted mutations have been funded. These programs are reaching fruition, and a variety of libraries of embryonic stem cells with defined mutations are now available. © 2010 Faculty of 1000 Ltd.
CITATION STYLE
Beier, D. R. (2010). New genetic resources for mammalian developmental biologists. F1000 Biology Reports. https://doi.org/10.3410/B2-72
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