A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 1-3 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
CITATION STYLE
Lacret, R., Oves-Costales, D., Gómez, C., Díaz, C., De La Cruz, M., Pérez-Victoria, I., … Reyes, F. (2015). New ikarugamycin derivatives with antifungal and antibacterial properties from streptomyces zhaozhouensis. Marine Drugs, 13(1), 128–140. https://doi.org/10.3390/md13010128
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