New ikarugamycin derivatives with antifungal and antibacterial properties from streptomyces zhaozhouensis

  • Lacret R
  • Oves-Costales D
  • Gómez C
 et al. 
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Abstract

A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 1-3 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).

Author-supplied keywords

  • Antibacterial
  • Antifungal
  • Ikarugamycin
  • Polycyclic tetramate macrolactams
  • Streptomyces zhaozhouensis

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Authors

  • Rodney Lacret

  • Daniel Oves-Costales

  • Cristina Gómez

  • Caridad Díaz

  • Mercedes De La Cruz

  • Ignacio Pérez-Victoria

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