New insights in the mechanism of microRNA-mediated target repression

  • Hafner M
  • Ascano M
  • Tuschl T
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Abstract

The microRNA-induced silencing complex (miRISC) protein TNRC6 (also called GW182) uses dispersed tryptophan-containing repeats in unstructured regions to recruit the CCR4–NOT nuclease complex leading to mRNA deadenylation and inhibition of translation initiation according to new research.

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