A new ionic liquids-based monolithic column for determination of caffeine and theophylline

  • Zhu T
  • Bi W
  • Row K
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The present study has concentrated on finding a new stationary phase in liquid chromatography. To improve the selectivity of monolithic column, a new ionic liquids–based (ILs-based) monolithic column (150  4.6 mm i.d.) is synthesized. Characteristic and evaluation of monolithic column are investigated by field emissionscanning electron microscopy (FE-SEM) and determination of caffeine and theophylline in high performance liquid chromatography (HPLC). FE-SEM images show that this monolithic column has a porosity structure. At the condition of mobile phase was 0.06 mol L1 Na2HPO4 (pH 9.0) and flow rate was 0.7 mL min1, a good linear relationship was demonstrated when the concentrations of caffeine and theophylline were in the range of 0.1–60.0 lg mL1. These two compounds can obtain better resolution on the ILsbased monolithic column than non-ILs monolithic column, and the recoveries ranged from 97.40% to 108.00% and the interday and intraday relative standard deviations were less than 5%. The HPLC method, developed in this study, was proved to be acceptable for drugs assay, and this ILsbased monolithic column as the stationary phase was a potential tool for future HPLC separation

Author-supplied keywords

  • Caffeine
  • HPLC
  • Ionic liquids
  • Monolithic column
  • Theophylline

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