New properties from PLA–PEO–PLA hydrogels

  • Tew G
  • Sanabria-DeLong N
  • Agrawal S
 et al. 
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Abstract

Polymeric materials are important in many medical applications. Regenerative
medicine offers the potential to repair or replace damaged tissue
and polymers are an essential component of many tissue engineering
approaches. Hydrogels have many advantageous properties but, generally,
lack robust mechanical properties. At the same time, mounting evidence
points to the importance of the matrix modulus when constructing
devices. In this context, triblock copolymers made from poly(L-lactide)-poly(ethylene
glycol)-poly(L-lactide) have been prepared and formulated into hydrogels.
Investigations into their mechanical properties found the elastic
modulus to be greater than 10 kPa which is at least one order of
magnitude stiffer than previously reported from macromolecules composed
of similar monomers. Part of the reason is the presence of crystalline
lactide domains. Creating hydrogels with tailored modulus across
the kPa range will likely have important ramifications in regenerative
medicine.

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Authors

  • Gregory N. Tew

  • Naomi Sanabria-DeLong

  • Sarvesh K. Agrawal

  • Surita R. Bhatia

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