New route to azaspirocycles via the organolithium-mediated conversion of ??-alkoxy aziridines into cyclopentenyl amines

  • Moore S
  • Coote S
  • O'Brien P
 et al. 
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A new three-step route to azaspirocycles, e.g. azaspirodecene I, involved organolithium-mediated conversion of β-alkoxy aziridines, e.g. butenylaziridinocyclopentane II, into substituted cyclopentenyl amines, e.g. III, and subsequent hydroboration and cyclization. This methodol. was utilized in the construction of the pentacyclic ring system of cephalotaxine. [on SciFinder(R)]

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  • Stephen P. Moore

  • Susannah C. Coote

  • Peter O'Brien

  • John Gilday

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