New tools for functional mammalian cancer genetics

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Abstract

Knowledge of the function of individual genes that encode components of cell-signalling pathways is crucial to our understanding of normal growth control and its deregulation in cancer, but we have functional information for only ∼15% of human genes at present. Several new technologies have recently become available to identify gene function in mammalian cells using high-throughput genetic screens. These new tools will make it possible to identify new and innovative classes of anticancer drugs, including those that show synthetic lethal interactions with cancer-specific mutations.

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Brummelkamp, T. R., & Bernards, R. (2003). New tools for functional mammalian cancer genetics. Nature Reviews Cancer. European Association for Cardio-Thoracic Surgery. https://doi.org/10.1038/nrc1191

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