Nickel-Catalyzed C-O/C-H Cross-Coupling Reactions for C-C Bond Formation

Abstract

Halides not required: Nickel-catalyzed C-O/C-H cross-couplings for the construction of C-C bonds have recently been disclosed. By carefully optimizing the nickel catalyst, new C-C bond-forming reactions were developed, and even quaternary stereogenic centers are now accessible in high yields from readily available phenoxide derivatives and hydrocarbons.