Nitroprusside in critically ill patients with left ventricular dysfunction and aortic stenosis

  • Khot U
  • Novaro G
  • Popović Z
 et al. 
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Abstract

BACKGROUND: Vasodilators are considered to be contraindicated in patients with severe aortic stenosis because of concern that they may precipitate life-threatening hypotension. However, vasodilators such as nitroprusside may improve myocardial performance if peripheral vasoconstriction is contributing to afterload. METHODS: We determined the response to intravenous nitroprusside in 25 patients with severe aortic stenosis and left ventricular systolic dysfunction. Patients were included in the study if they had been admitted to the intensive care unit for invasive hemodynamic monitoring of heart failure and if they had a depressed ejection fraction (

Author-supplied keywords

  • Aged
  • Aortic Valve
  • Aortic Valve Stenosis
  • Critical Illness
  • Female
  • Heart Failure
  • Hemodynamics
  • Humans
  • Male
  • Nitroprusside
  • Pressure
  • Prospective Studies
  • Stroke Volume
  • Vasodilator Agents
  • Ventricular Dysfunction: Left

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Authors

  • U N Khot

  • G M Novaro

  • Z B Popović

  • R M Mills

  • J D Thomas

  • E M Tuzcu

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