Novel porous graphene oxide and hydroxyapatite nanosheets-reinforced sodium alginate hybrid nanocomposites for medical applications

  • Xiong G
  • Luo H
  • Zuo G
 et al. 
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Abstract

a b s t r a c t Graphene oxide (GO) and hydroxyapatite (HAp) are frequently used as reinforcements in polymers to improve mechanical and biological properties. In this work, novel porous hybrid nanocomposites consisting of GO, HAp, and sodium alginate (SA) have been prepared by facile solution mixing and freeze drying in an attempt to obtain a scaffold with desirable mechanical and biological properties. The as-prepared porous GO/HAp/SA hybrid nano-composites were characterized by SEM, XRD, FTIR, TGA, and mechanical testing. In addition, preliminary cell be-havior was assessed by CCK8 assay. It is found that the GO/HAp/SA nanocomposites show improved compressive strength and modulus over neat SA and HAp/SA nanocomposites. CCK8 results reveal that the GO/HAp/SA nano-composites show enhanced cell proliferation over neat SA and GO/SA nanocomposite. It has been demonstrated that GO/HAp20/SA holds promise in bone tissue engineering.

Author-supplied keywords

  • Graphene oxide
  • Hydroxyapatite
  • Nanocomposites
  • Scaffold
  • Sodium alginate

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Authors

  • Guangyao Xiong

  • Honglin Luo

  • Guifu Zuo

  • Kaijing Ren

  • Yizao Wan

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