Novel spiro-sesquiterpene from the mushroom Anthracophyllum sp. BCC18695

  • Intaraudom C
  • Boonyuen N
  • Supothina S
 et al. 
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Abstract

novel spiro-sesquiterpene, anthracophyllic acid (1), and a new aristolane sesquiterpene, anthracophyllone (2), were isolated from the mushroom Anthracophyllum sp. BCC18695, together with seven known compounds including aurisins A (3), G (4), K (5), nambinones A, C, axinysones A, and B. The relative configuration of 1 and the hitherto unknown absolute stereochemistry of 3 were determined based on X-ray spectroscopic data. Biological activities including antimalarial activity against Plasmodium falciparum K1 strain, antibacterial property against Bacillus cereus, and cytotoxicity against MCF-7, KB, NCI-H187, and Vero cells of the isolated compounds were also evaluated. © 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Anthracophyllum
  • Antimalarial
  • Basidiomycetes
  • Cytotoxicity
  • Sesquiterpenes

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