Nramp1 phagocyte intracellular metal withdrawal defense

  • Cellier M
  • Courville P
  • Campion C
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Abstract

Natural resistance-associated macrophage proteins (Nramp) are multispecific symporters facilitating proton-dependent import of divalent metals. Nramp1 restricts microbial access to essential micro-nutrients such as iron and manganese within professional phagosomes. Increased understanding of Nramp1 roles in human phagocytes will be useful for future therapeutic approaches against selected infectious and immune diseases. © 2007 Elsevier Masson SAS. All rights reserved.

Author-supplied keywords

  • Divalent cations
  • Phagosomes
  • Transport proteins

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Authors

  • Mathieu F. Cellier

  • Pascal Courville

  • Carole Campion

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