NTCP opens the door for hepatitis B virus infection

  • Yan H
  • Liu Y
  • Sui J
 et al. 
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Abstract

Abstract A liver bile acids transporter, sodium taurocholate cotransporting polypeptide (NTCP, encoded by SLC10A1) was recently identified as a functional receptor for hepatitis B virus (HBV) and its satellite hepatitis D virus (HDV). NTCP-complemented human hepatoma HepG2 cells (HepG2-NTCP) were shown to support infection of HBV and HDV in vitro, providing a much-needed and convenient cell culture system for the viruses. Identification of NTCP as a functional receptor for HBV has significantly advanced our understanding of the viral life cycle and opened new opportunities for developing anti-HBV interventions. This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B".

Author-supplied keywords

  • Cell culture
  • Drug development
  • Hepatitis B virus
  • Hepatitis D virus
  • Receptor
  • Sodium taurocholate cotransporting polypeptide (NT

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Authors

  • Huan Yan

  • Yang Liu

  • Jianhua Sui

  • Wenhui Li

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