Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction.

  • Misra A
  • SB H
  • Knuefermann P
 et al. 
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BACKGROUND: Previous studies have shown that tumor necrosis factor (TNF) confers cytoprotective responses in cardiac myocytes. However, the mechanisms for the cytoprotective effects of TNF remain unknown. Given that TNF signals through nuclear factor kappaB (NF-kappaB) and given that NF-kappaB mediates cytoprotective responses, we asked whether NF-kappaB activation conferred cytoprotective responses in acute myocardial ischemia/infarction. METHODS AND RESULTS: We examined infarct size and the prevalence of apoptosis in transgenic mice harboring cardiac-restricted expression of a mutated IkappaBalpha protein (IkappaBalphaDeltaN) that prevents nuclear translocation of NF-kappaB in cardiac myocytes. Triphenyltetrazolium chloride staining showed that infarct size was approximately 50% greater (P

Author-supplied keywords

  • Animals
  • Apoptosis
  • Coronary Vessels
  • Cytoprotection
  • I-kappa B Proteins
  • Ligation
  • Mice
  • Mice, Transgenic
  • Myocardial Infarction
  • Myocardial Ischemia
  • Myocytes, Cardiac
  • NF-kappa B
  • complications
  • etiology
  • genetics
  • metabolism
  • pathology
  • surgery

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  • A Misra

  • Haudek SB

  • P Knuefermann

  • Vallejo JG

  • Chen ZJ

  • Michael LH

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