Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction.

  • Misra A
  • SB H
  • Knuefermann P
 et al. 
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

BACKGROUND: Previous studies have shown that tumor necrosis factor (TNF) confers cytoprotective responses in cardiac myocytes. However, the mechanisms for the cytoprotective effects of TNF remain unknown. Given that TNF signals through nuclear factor kappaB (NF-kappaB) and given that NF-kappaB mediates cytoprotective responses, we asked whether NF-kappaB activation conferred cytoprotective responses in acute myocardial ischemia/infarction. METHODS AND RESULTS: We examined infarct size and the prevalence of apoptosis in transgenic mice harboring cardiac-restricted expression of a mutated IkappaBalpha protein (IkappaBalphaDeltaN) that prevents nuclear translocation of NF-kappaB in cardiac myocytes. Triphenyltetrazolium chloride staining showed that infarct size was approximately 50% greater (P

Author-supplied keywords

  • Animals
  • Apoptosis
  • Coronary Vessels
  • Cytoprotection
  • I-kappa B Proteins
  • Ligation
  • Mice
  • Mice, Transgenic
  • Myocardial Infarction
  • Myocardial Ischemia
  • Myocytes, Cardiac
  • NF-kappa B
  • complications
  • etiology
  • genetics
  • metabolism
  • pathology
  • surgery

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • A Misra

  • Haudek SB

  • P Knuefermann

  • Vallejo JG

  • Chen ZJ

  • Michael LH

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free