Numerical solution of initial boundary value problems involving Maxwell's equations in isotropic media.

  • Yee K
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Abstract

Understanding the complex molecular alterations related to engineered nanomaterial (ENM) exposure is essential for carrying out toxicity assessment. Current experimental paradigms rely on both in vitro and in vivo exposure setups that often are difficult to compare, resulting in questioning the real efficacy of cell models to mimic more complex exposure scenarios at the organism level. Here, we have systematically investigated transcriptomic responses of the THP-1 macrophage cell line and lung tissues of mice, after exposure to several carbon nanomaterials (CNMs). Under the assumption that the CNM exposure related molecular alterations are mixtures of signals related to their intrinsic properties, we inferred networks of responding genes, whose expression levels are coordinately altered in response to specific CNM intrinsic properties. We observed only a minute overlap between the sets of intrinsic property-correlated genes at different exposure scenarios, suggesting specific transcriptional programs work...

Author-supplied keywords

  • carbon nanomaterials
  • gene networks
  • mechanism of action
  • network response modules
  • pathways of toxicity
  • toxicogenomics
  • transcriptomics

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Authors

  • K. S. Yee

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