Obesity increases the risk for high-grade prostate cancer: Results from the REDUCE study

  • Vidal A
  • Howard L
  • Moreira D
 et al. 
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Background: Studies suggest that obesity is associated with lower risk of prostate cancer but more aggressive cancers. As obesity lowers PSA levels, these observations may be influenced by detection bias. We examined the association between obesity and risk of low- and high-grade prostate cancer in REDUCE, in which biopsies were largely independent of PSA. Methods: The REDUCE study tested dutasteride for prostate cancer risk reduction in men with a PSA of 2.5 to 10.0 ng/mL and a negative biopsy. Study participants included 6,729 men who underwent at least one on-study biopsy. The association between baseline body mass index (BMI 2 normal weight; 25-29.9 kg/m2 overweight; and >30 kg/m2 obese) and risk of high-grade (Gleason >7) or low-grade prostate cancer (Gleason

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  • Daniel MoreiraUniversity of Illinois Chicago

  • Adriana C. Vidal

  • Lauren E. Howard

  • Ramiro Castro-Santamaria

  • Gerald L. Andriole

  • Stephen J. Freedland

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