Olanzapine in the treatment of refractory migraine and chronic daily headache

S.D. S, M.F.P. P, M.M. H, A.L. S, W.B. Y, T.D. R ...see all

Headache, vol. 42, issue 6 (2002) pp. 515-518 Published by Blackwell Publishing Inc.

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Background. - Olanzapine, a thienobenzodiazepine, is a new "atypical" antipsychotic drug. Olanzapine's pharmacologic properties suggest it would be effective for headaches, and its propensity for inducing acute extrapyramidal reactions or tardive dyskinesia is relatively low. We thus decided to assess the value of olanzapine in the treatment of chronic refractory headache. Methods. - We reviewed the records of 50 patients with refractory headache who were treated with olanzapine for at least 3 months. All previously had failed treatment with at least four preventative medications. The daily dose of olanzapine varied from 2.5 to 35 mg; most patients (n = 19) received 5 mg or 10 mg (n = 17) a day. Results. - Treatment resulted in a statistically significant decrease in headache days relative to baseline, from 27.5 +/- 4.9 before treatment to 21.1+/-10.7 after treatment (P

Author-supplied keywords

  • *chronic pain/dt [Drug Therapy]
  • *headache/dt [Drug Therapy]
  • *migraine/dt [Drug Therapy]
  • *olanzapine/ae [Adverse Drug Reaction]
  • *olanzapine/dt [Drug Therapy]
  • adult
  • agitation
  • akathisia/si [Side Effect]
  • article
  • bipolar disorder
  • clinical article
  • comorbidity
  • constipation/si [Side Effect]
  • depressive psychosis
  • disease severity
  • drug efficacy
  • dystonia/si [Side Effect]
  • edema/si [Side Effect]
  • extrapyramidal symptom/si [Side Effect]
  • female
  • human
  • male
  • mania
  • myalgia/si [Side Effect]
  • nausea/si [Side Effect]
  • neuroleptic agent
  • priority journal
  • prophylaxis
  • rating scale
  • retrospective study
  • side effect/si [Side Effect]
  • somnolence/si [Side Effect]
  • tardive dyskinesia/si [Side Effect]
  • treatment failure
  • treatment outcome
  • tremor/si [Side Effect]
  • vertigo/si [Side Effect]
  • weight gain

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  • Silberstein S.D.

  • Peres M.F.P.

  • Hopkins M.M.

  • Shechter A.L.

  • Young W.B.

  • Rozen T.D.

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