Skip to content
Journal article

Olanzapine in the treatment of refractory migraine and chronic daily headache

Silberstein S, Peres Mario F, Hopkins M, Shechter A, Young W, Rozen T ...see all

Headache, vol. 42, issue 6 (2002) pp. 515-518

  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.
  • N/A


    ScienceDirect users who have downloaded this article.
Sign in to save reference


BACKGROUND: Olanzapine, a thienobenzodiazepine, is a new "atypical" antipsychotic drug. Olanzapine's pharmacologic properties suggest it would be effective for headaches, and its propensity for inducing acute extrapyramidal reactions or tardive dyskinesia is relatively low. We thus decided to assess the value of olanzapine in the treatment of chronic refractory headache. METHODS: We reviewed the records of 50 patients with refractory headache who were treated with olanzapine for at least 3 months. All previously had failed treatment with at least four preventative medications. The daily dose of olanzapine varied from 2.5 to 35 mg; most patients (n = 19) received 5 mg or 10 mg (n = 17) a day. RESULTS: Treatment resulted in a statistically significant decrease in headache days relative to baseline, from 27.5 +/- 4.9 before treatment to 21.1+/-10.7 after treatment (P

Author-supplied keywords

  • Antipsychotic Agents: TU, therapeutic use
  • Benzodiazepines
  • Chronic Disease
  • Headache Disorders: DT, drug therapy
  • Humans
  • Migraine Disorders: DT, drug therapy
  • Migraine Disorders: PC, prevention & control
  • Pain, Intractable: DT, drug therapy
  • Pirenzepine: AA, analogs & derivatives
  • Pirenzepine: TU, therapeutic use
  • Retrospective Studies
  • Treatment Outcome

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Stephen D Silberstein

  • F P Peres Mario

  • Mary M Hopkins

  • Aaron L Shechter

  • William B Young

  • Todd D Rozen

Cite this document

Choose a citation style from the tabs below