Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients.

  • An W
  • Lee S
  • Son Y
 et al. 
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Vitamin D deficiency, low levels of fetuin-A, and fibroblast growth factor 23 (FGF-23) are related to vascular calcification, which is associated with cardiovascular disease. We hypothesized that omega-3 fatty acid (FA), which has cardioprotective properties, modifies vitamin D status, fetuin-A, and FGF-23 levels in dialysis patients. In a randomized, open-label, controlled study, a total of 47 patients treated with dialysis for at least 1 year were randomized to treatment for 6 months with omega-3 FAs (Omacor, 3 g/d; Pronova, Sandefjord, Norway) or a control group. Levels of fetuin-A and FGF-23 were measured by enzyme-linked immunoassay, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were measured by radioimmunoassay. The mean age of the enrolled patients was 57.4 ± 10.4 years, and mean dialysis duration was 46.5 ± 28.1 months. Twenty-seven hemodialysis patients and 16 peritoneal dialysis patients finished this trial. After 6 months, the levels of 1,25-dihydroxyvitamin D and fetuin-A were significantly increased in the group taking the omega-3 FA supplement compared with baseline. Levels of calcium, phosphorous, parathyroid hormone, 25-hydroxyvitamin D, FGF-23, and lipid profiles were not significantly changed in the omega-3 FA-supplemented group after 6 months compared with baseline. The erythrocyte membrane contents of eicosapentaenoic acid and docosahexaenoic acid were significantly increased, and oleic acid content was significantly decreased in the omega-3 FA-supplemented group after 6 months compared with baseline. Regarding vascular calcification and cardiovascular disease, omega-3 FA supplementation may have a clinical benefit caused by activating vitamin D, increasing fetuin-A levels, and modifying erythrocyte membrane FA contents in dialysis patients.

Author-supplied keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Calcium
  • Calcium: blood
  • Cardiovascular Diseases
  • Cardiovascular Diseases: drug therapy
  • Cardiovascular Diseases: physiopathology
  • Diet
  • Dietary Supplements
  • Docosahexaenoic Acids
  • Docosahexaenoic Acids: administration & dosage
  • Drug Combinations
  • Eicosapentaenoic Acid
  • Eicosapentaenoic Acid: administration & dosage
  • Energy Intake
  • Erythrocyte Membrane
  • Erythrocyte Membrane: drug effects
  • Erythrocyte Membrane: metabolism
  • Fatty Acids, Omega-3
  • Fatty Acids, Omega-3: administration & dosage
  • Fatty Acids, Omega-3: blood
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oleic Acid
  • Oleic Acid: blood
  • Parathyroid Hormone
  • Parathyroid Hormone: blood
  • Peritoneal Dialysis
  • Phosphorus
  • Phosphorus: blood
  • Radioimmunoassay
  • Renal Dialysis
  • Vascular Calcification
  • Vascular Calcification: drug therapy
  • Vascular Calcification: physiopathology
  • Vitamin D
  • Vitamin D: administration & dosage
  • Vitamin D: analogs & derivatives
  • Vitamin D: blood
  • alpha-2-HS-Glycoprotein
  • alpha-2-HS-Glycoprotein: analysis

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  • Won Suk An

  • Su Mi Lee

  • Young Ki Son

  • Seong Eun Kim

  • Ki Hyun Kim

  • Jin Yeong Han

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