On-chip THz detection of biomaterials: A numerical study

  • Baras T
  • Kleine-Ostmann T
  • Koch M
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Abstract

The marker-free on-chip distinction betweenhybridised (double-stranded) DNA (HDNA) anddenatured (single-stranded) DNA (DDNA) hasrecently been demonstrated using ultrashortelectrical pulses. The electrical THzpulses propagate in integrated waveguidesincorporating resonant THz structures ontowhich the genetic material is deposited.For a possible future realisation of a highthroughput array, it is crucial to optimizethe experimental parameters and theresonant structure. In this paper weperform a first numerical study ofdifferent resonator geometries and examinethe influence of critical experimentalparameters on the transmissioncharacteristics of the resonant structures.Our simulations demonstrate that the ringresonator shows a comparable performance tothe parallel-coupled resonator previouslyused in a first demonstration by Nagel andcoworkers.

Author-supplied keywords

  • Lab-on-chip
  • Marker-free DNA testing
  • Numerical simulations
  • On-chip DNA analysis
  • Parallel-coupled filter
  • Ring resonator
  • THz on-chip detection
  • THz spectroscopy

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Authors

  • T. Baras

  • T. Kleine-Ostmann

  • M. Koch

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