One-pot synthesis of tricyclic dihydropyrimidine derivatives and their biological evaluation

  • Kaur N
  • Kaur K
  • Raj T
 et al. 
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Abstract

A series of tricyclic dihydropyrimidine derivatives were synthesized using a one-pot, three-component Traube-Schwarz reaction in the presence of catalyst Zn(ClO4)(2)center dot 6H(2)O. All the purified compounds were evaluated for their in vitro anticancer activity against three different cancer cell lines such as prostate cancer cells (PO), lung cancer cells (NCI-H1299) and colon cancer cells (HCT116). In vitro DNA-intercalation ability of the compounds was investigated by UV vis absorption spectroscopy, showing the insertion of compound into the DNA base pairs and a strong interaction with the DNA double helix. (C) 2014 Elsevier Ltd. All rights reserved.

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Authors

  • N Kaur

  • K Kaur

  • T Raj

  • G Kaur

  • A Singh

  • T Aree

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