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Optimal use of ??-blockers in high-risk hypertension: A guide to dosing equivalence

McGill J ...see all

Vascular Health and Risk Management, vol. 6, issue 1 (2010) pp. 363-372

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Abstract

Hypertension is the number one diagnosis made by primary care physicians, placing them in a unique position to prescribe the antihypertensive agent best suited to the individual patient. In individuals with diabetes mellitus, blood pressure (BP) levels>130/80 mmHg confer an even higher risk for cardiovascular and renal disease, and these patients will benefit from aggressive antihypertensive treatment using a combination of agents. beta-blockers are playing an increasingly important role in the management of hypertension in high-risk patients. beta-blockers are a heterogeneous class of agents, and this review presents the differences between beta-blockers and provides evidence-based protocols to assist in understanding dose equivalence in the selection of an optimal regimen in patients with complex needs. The clinical benefits provided by beta-blockers are only effective if patients adhere to medication treatment long term. beta-blockers with proven efficacy, once-daily dosing, and lower side effect profiles may become instrumental in the treatment of hypertensive diabetic and nondiabetic patients.

Author-supplied keywords

  • Antihypertensive
  • Atenolol
  • Blood pressure
  • Carvedilol
  • Labetalol
  • Metoprolol
  • Nebivolol

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