Optimization of random time domain sampling in multidimensional NMR

  • Kazimierczuk K
  • Zawadzka A
  • Koźmiński W
  • 43


    Mendeley users who have this article in their library.
  • 67


    Citations of this article.


The detailed description of rules for generation of different random sampling schemes is shown and discussed with regard to Multidimensional Fourier Transform (MFT). The influence of different constrained random sampling schedules on FT of constant signal, i.e., Point Spread Function (PSF), is analyzed considering artifacts level and distribution. We found that Poisson disk sampling schedule, which provides a large low-artifact area in the signal vicinity, is the method of choice in the case of nonlinear sampling of time domain in NMR experiments. We have verified the new sampling schemes by application to the 3D HNCACB and15N-edited NOESY-HSQC spectra acquired for13C,15N labeled ubiquitin sample. © 2008 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • Fast multidimensional data acquisition
  • Multidimensional Fourier Transform
  • Multidimensional NMR spectroscopy
  • Poisson disk
  • Proteins
  • Random data sampling

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free