Optimization of vitamin suppletion after Roux-en-Y gastric bypass surgery can lower postoperative deficiencies:A randomized controlled trial

  • Dogan K
  • Aarts E
  • Koehestanie P
 et al. 
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Iron, vitamin B12, and folic acid deficiencies are among the most common deficiencies occurring after laparoscopic Roux-en-Y gastric bypass (LRYGB). The present study evaluates the effectiveness of a specially designed multivitamin supplement (WLS Forte, Fit- ForMe, Rotterdam, the Netherlands) specifically developed for LRYGB patients. A triple-blind, randomized, 12-month study was conducted comparing WLS forte with a standard multivitamin supplement (sMVS) containing approximately 100% of the recommended daily allowance (RDA) for iron, vitamin B12, and folic acid. WLS Forte contains vitamin B12 14000% RDA, iron 500% RDA, and folic acid 300% RDA. In total, 148 patients (74 in each group) underwent a LRYGB procedure. Baseline characteristics were similar for both groups. Per protocol analysis demonstrated that sMVS treatment was associated with a decline in ferritin (-24.4±70.1μg/L) and vitamin B12 (-45.9±150.3 pmol/L) over 12 months, whereas in WLS Forte patients, ferritin remained stable (+3.2-93.2μg/L) and vitamin B12 increased significantly (+55.1±144.2 pmol/L). The number of patients developing ferritin or vitamin B12 deficiency was significantly lower with WLS Forte compared with sMVS (P

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  • Kemal Dogan

  • Edo O. Aarts

  • Parweez Koehestanie

  • Nadine Ploeger

  • Hans De Boer

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