Orally disintegrating mini-tablets (ODMTs)--a novel solid oral dosage form for paediatric use.

  • Stoltenberg I
  • Breitkreutz J
  • 19


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The new European regulations on paediatric medicines and recent WHO recommendations have induced an increased need for research into novel child-appropriate dosage forms. The aim of this study was the development of orally disintegrating mini-tablets (ODMTs) as a suitable dosage form for paediatric patients. The suitability of five commercially available ready-to-use tableting excipients, Ludiflash, Parteck ODT, Pearlitol Flash, Pharmaburst 500 and Prosolv ODT, to be directly compressed into mini-tablets, with 2 mm in diameter, was examined. All of the excipients are based on co-processed mannitol. Drug-free ODMTs and ODMTs with a child-appropriate dose of hydrochlorothiazide were investigated. ODMTs could be produced with all investigated excipients. ODMTs with a sufficient crushing strength >7 N and a low friability

Author-supplied keywords

  • Administration, Oral
  • Antihypertensive Agents
  • Antihypertensive Agents: administration & dosage
  • Antihypertensive Agents: chemistry
  • Child
  • Child, Preschool
  • Compressive Strength
  • Drug Carriers
  • Drug Carriers: chemistry
  • Drug Compounding
  • Drug Compounding: methods
  • Drug Delivery Systems
  • Excipients
  • Excipients: chemistry
  • Humans
  • Hydrochlorothiazide
  • Hydrochlorothiazide: administration & dosage
  • Hydrochlorothiazide: chemistry
  • Lubricants
  • Particle Size
  • Powders
  • Solubility
  • Surface-Active Agents
  • Surface-Active Agents: chemistry
  • Tablets
  • Tablets: chemistry

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  • I Stoltenberg

  • J Breitkreutz

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