Orexins/hypocretins in the ob/ob mouse: Hypothalamic gene expression, peptide content and metabolic effects

  • Stricker-Krongrad A
  • Richy S
  • Beck B
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Abstract

Orexins (forms A and B) belong to a new family of peptides that, as neuropeptide Y (NPY), stimulate food intake when centrally injected. The ob/ob mouse is a well-characterized model of hyperphagia and obesity associated with strong metabolic disturbances and a central dysregulation of peptides involved in the control of feeding. In the present report, we investigated the hypocretin (Hcrt)/orexin (OX) peptide pathway in lean and ob/ob mice. Prepro-Hcrt/OX mRNA expression, measured by in situ hybridization was restricted to the lateral hypothalamus area. It was significantly decreased in ob/ob mice (-18%; p

Author-supplied keywords

  • Central regulation of feeding
  • Energy expenditure
  • Food intake
  • Obesity

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Authors

  • Alain Stricker-Krongrad

  • Sébastien Richy

  • Bernard Beck

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