Organic solvent nanofiltration in pharmaceutical industry

  • Buonomenna M
  • Bae J
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Abstract

Organic solvent nanofiltration (OSN) is a promising energy and waste efficient unit process to separate mixtures down to a molecular level, which gained attention in the pharmaceutical industry, in particular in the process development of Active Pharmaceutical Ingredients (APIs). This article focuses on all aspects related to OSN (i.e., membrane materials, commercial membranes, transport theories, applications) to understand the role of this technology in pharmaceutical industry. The most important results in the last five years on OSN applications in the process development of APIs are reviewed extensively.

Author-supplied keywords

  • Active pharmaceutical ingredients (APIs)
  • Genotoxin impurities (GTIs)
  • Hybrid processes
  • Membrane enhanced peptide synthesis (MEPS)
  • Organic solvent nanofiltration
  • Product purification
  • Solvent exchange
  • Solvent resistant nanofiltration

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Authors

  • M. G. Buonomenna

  • J. Bae

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