Orthogonal riboswitches for tuneable coexpression in bacteria

  • Dixon N
  • Robinson C
  • Geerlings T
 et al. 
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Abstract

Orthogonal gene control: Orthogonal riboswitches can be deployed in the same bacterial cell to independently control the coexpression of multiple genes in a dose-dependent response to distinct synthetic small molecules. This technique allows convenient access to highly dynamic expression landscapes and desirable protein stoichiometries.

Author-supplied keywords

  • RNA
  • gene expression
  • riboswitches
  • synthetic biology

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Authors

  • Neil Dixon

  • Christopher J. Robinson

  • Torsten Geerlings

  • John N. Duncan

  • Sheona P. Drummond

  • Jason Micklefield

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