Skip to content
Journal article

Osmotic capsules: A universal oral, controlled-release drug delivery dosage form

Waterman K, Goeken G, Konagurthu S, Likar M, MacDonald B, Mahajan N, Swaminathan V ...see all

Journal of Controlled Release, vol. 152, issue 2 (2011) pp. 264-269

  • 42

    Readers

    Mendeley users who have this article in their library.
  • 21

    Citations

    Citations of this article.
  • 5.9k

    Views

    ScienceDirect users who have downloaded this article.
Sign in to save reference

Abstract

An osmotic, oral, controlled-release capsule is described. This capsule provides drug delivery at fixed delivery rates (T80% = 6 or 14 h) independent of drug properties (e.g., solubility) or drug loading, thereby allowing rapid development of investigational or commercial drugs, especially for proof-of-concept type clinical studies. The capsule body and cap are prepared with cellulose acetate and polyethylene glycol in acetone and water using high density polyethylene molds as templates and a conventional tablet pan coater. After the shells are removed from the molds manually, a laser hole is drilled in the end of the capsule body. The drug is introduced as a shaped tablet admixed with polyethylene oxide. A "push" tablet consisting of high molecular weight polyethylene oxide, microcrystalline cellulose, and sodium chloride is also inserted into the capsule body. The capsule halves lock together due to ridges, alleviating the need for a banding operation. ?? 2011 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Oral controlled release
  • Osmotic drug delivery

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • Kenneth C. Waterman

  • G. Scott Goeken

  • Sanjay Konagurthu

  • Michael D. Likar

  • Bruce C. MacDonald

  • Nidhi Mahajan

Cite this document

Choose a citation style from the tabs below