Osteoprotegerin ligand: A common link between osteoclastogenesis, lymph node formation and lymphocyte development

  • Kong Y
  • Boyle W
  • Penninger J
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Abstract

The TNF-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL or ODF) has been identified as the osteoclast differentiation factor and a regulator of T cell-dendritic cell interactions in the immune system. Surprisingly, the same molecule was identified as a crucial factor in early lymphocyte development and lymph node organogenesis. We will discuss the role of OPGL in bone remodelling and the immune system.

Author-supplied keywords

  • Lymph node genesis
  • Lymphocyte development
  • Osteoclastogenesis
  • Osteoprotegerin ligand

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Authors

  • Young Yun Kong

  • William J. Boyle

  • Josef M. Penninger

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