Outcomes of in vitro fertilization with preimplantation genetic diagnosis: An analysis of the Unites States Assisted Reproductive Technology Surveillance Data, 2011-2012

  • Chang J
  • Boulet S
  • Jeng G
 et al. 
  • 17


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Objective: To assess the characteristics of IVF cycles for which preimplantation genetic diagnosis (PGD) was used and to evaluate indications for PGD and treatment outcomes associated with this procedure as compared with cycles without PGD with the data from the U.S. National ART Surveillance System. Design: Retrospective cohort study. Setting: None. Patient(s): Fresh autologous cycles that involved transfer of at least one embryo at blastocyst when available. Intervention(s): None. Main Outcome Measure(s): PGD indications and age-specific reproductive outcomes. Result(s): There were a total of 97,069 non-PGD cycles and 9,833 PGD cycles: 55.6% were performed for aneuploidy screening (PGD Aneuploidy), 29.1% for other reasons (PGD Other), and 15.3% for genetic testing (PGD Genetic). In comparison to non-PGD cycles, PGD Aneuploidy cycles showed a decreased odds of miscarriage among women 35-37 years (adjusted odds ratio [aOR] 0.62; 95% CI, 0.45-0.87) and women >37 years (aOR 0.55; 95% CI, 0.43-0.70); and an increased odds of clinical pregnancy (aOR 1.18; 95% CI, 1.05-1.34), live-birth delivery (aOR 1.43; 95% CI, 1.26-1.62), and multiple-birth delivery (aOR 1.98; 95% CI, 1.52-2.57) among women >37 years. Conclusion(s): Aneuploidy screening was the most common indication for PGD. Use of PGD was not observed to be associated with an increased odds of clinical pregnancy or live birth for women 35 years, but an increased odds of a live-birth and a multiple live-birth delivery among women >37 years.

Author-supplied keywords

  • Aneuploidy
  • Chromosomal abnormality
  • Genetic
  • In vitro fertilization
  • Preimplantation genetic diagnosis

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Jeani Chang

  • Sheree L. Boulet

  • Gary Jeng

  • Lisa Flowers

  • Dmitry M. Kissin

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free