Oxidative degradation of pharmaceuticals: Theory, mechanisms and inhibition

  • Hovorka S
  • Schöneich C
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Abstract

Oxidation is a common pathway for drug degradation in liquid and solid formulations. The present article reviews mechanistic details of autoxidation and chain oxidation processes, as well as the oxidation of selected functional groups commonly affected in drugs.

Author-supplied keywords

  • Autoxidation
  • Chain reaction
  • Oxidation
  • Oxidative degradation
  • Reactive oxygen species

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