Oxidative mechanism of arsenic toxicity and carcinogenesis

  • Shi H
  • Shi X
  • Liu K
  • 133

    Readers

    Mendeley users who have this article in their library.
  • 409

    Citations

    Citations of this article.

Abstract

Arsenic is a known toxin and carcinogen that is present in industrial settings and in the environment. The mechanisms of disease initiation and progression are not fully understood. In the last a few years, there has been increasing evidence of the correlation between the generation of reactive oxygen species (ROS), DNA damage, tumor promotion, and arsenic exposure. This article summarizes the current literature on the arsenic mediated generation of ROS and reactive nitrogen species (RNS) in various biological systems. This article also discusses the role of ROS and RNS in arsenic-induced DNA damage and activation of oxidative sensitive gene expression.

Author-supplied keywords

  • Arsenic
  • Carcinogenesis
  • Free radicals
  • Oxidative stress
  • Signal transduction

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Honglian Shi

  • Xianglin Shi

  • Ke Jian Liu

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free