p300 in Prostate Cancer Proliferation and Progression

  • Debes J
  • Sebo T
  • Lohse C
 et al. 
  • 16


    Mendeley users who have this article in their library.
  • 146


    Citations of this article.


Although prostate cancer (PCa) is the most frequently diagnosed can-cer in males, little is known about the mechanisms involved in its pro-gression. Recent in vitro studies suggest that coactivators of the androgen receptor play an important role in PCa progression. We have shown previously that p300 is involved in androgen receptor transactivation. In the present work, we studied 95 patients with biopsy-proven PCa who underwent prostatectomy as treatment of their tumors between 1995 and 1998. We found that p300 correlated with in vivo proliferation (P ‫؍‬ 0.009) as determined by MIB-I expression. Moreover, high levels of p300 in biopsies predicted larger tumor volumes (P < 0.001), extraprostatic ex-tension (P ‫؍‬ 0.003), and seminal vesicle involvement (P ‫؍‬ 0.002) at prostatectomy, as well as PCa progression after surgery (P ‫؍‬ 0.01). Furthermore, we found that the disruption of p300 transcripts through small interfering RNA inhibited PCa cell proliferation both at the basal level and on interleukin 6 stimulation. We conclude that p300 plays an important role in PCa cell prolifera-tion, as well as PCa progression.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Jose D. Debes

  • Thomas J. Sebo

  • Christine M. Lohse

  • Linda M. Murphy

  • De Anna L. Haugen

  • Donald J. Tindall

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free