p53 : Structure , Function and Therapeutic Applications

  • Bai L
  • Zhu W
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Since the p53tumor suppressor gene has been found to be mutated in more than 50% of human cancers, it has attracted the interest of numerous researchers. The capacity of p53 for multiple biological functions can be attributed to its ability to act as a se- quence-specific transcription factor to regulate expression of over one hundred differ- ent targets, and thus to modulate various cellular processes including apoptosis, cell cycle arrest and DNA repair. The p53 protein with its unique C- and N-terminal struc- tures is rigidly modulated by several important biological processes such as phos- phorylation, acetylation and ubiquitination, through which it effectively regulates cell growth and cell death. p53mutations can lead either to loss or change of p53 binding activity to its downstream targets and may thus induce aberrant cell proliferation, with consequent malignant cellular transformation. Based on p53s critical role in carcino- genesis, scientists have developed multiple effective strategies for treating cancer by enhancing function of wild-type p53 or increasing p53 stability. This review will focus on (i) discussing of the relationship between p53 structure and function, (ii) p53muta- tions, and (iii) recent strategies for improving the efficacy of cancer treatment by therapeutic manipulation of p53.

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  • Ling Bai

  • Wei-guo Zhu

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