In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1 year of follow-up

  • Emad Y
  • Anbar A
  • Abo-Elyoun I
 et al. 
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Abstract

This study aimed to determine the frequency of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies in a cohort of patients with palindromic rheumatism (PR) and to find determinants for progression to rheumatoid arthritis (RA). All new cases of PR (n=90) were included prospectively and followed up for 1 year, and a comparison group of RA cases (n=70) was also included. At study entry in all patients in both groups, RF and anti-CCP antibodies were tested, and the findings were compared and correlated. In the PR group at presentation, RF was positive in 30 patients (33.3%) and, in the RA group, in 45 patients (64.3%). Anti-CCP antibodies were positive in 35 patients (38.9%) with PR and in 58 patients (82.9%) with RA. In the PR group, positive correlations were observed between RF and C-reactive protein (CRP) (p=0.036), while anti-CCP positively correlated with disease duration (p=0.015) and CRP (p

Author-supplied keywords

  • Anti-cyclic citrullinated peptide antibodies (anti-CCP)
  • Palindromic rheumatism (PR)
  • Rheumatoid arthritis (RA)
  • Rheumatoid factor (RF)
  • Undifferentiated arthritis (UA)

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Authors

  • Yasser Emad

  • Ashraf Anbar

  • Ihab Abo-Elyoun

  • Nashwa El-Shaarawy

  • Hadeel Al-Hanafi

  • Hatem Darwish

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