The pancreas as a source of cardiovascular cell activating factors

  • Kistler E
  • Hugli T
  • Schmid-Schönbein G
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Abstract

Physiological shock leads to elevated levels of plasma factors that activate circulating leukocytes and endothelial cells, thereby compromising microvascular functions. The nature and source of these plasma-derived activators are unknown. To examine the possible origin of these factors, we homogenized rat internal organs and measured their activity on cardiovascular cells in vivo and in vitro.

Author-supplied keywords

  • Endothelium
  • Free radicals
  • Neutrophil
  • Protease
  • Pseudopod formation
  • Shock

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Authors

  • Erik B. Kistler

  • Tony E. Hugli

  • Geert W. Schmid-Schönbein

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