Pandemic (H1N1) 2009 influenza in the UK: clinical and epidemiological findings from the first few hundred (FF100) cases.

  • McLean E
  • Pebody R
  • Campbell C
 et al. 
  • 12


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


The UK was one of few European countries to document a substantial
wave of pandemic (H1N1) 2009 influenza in summer 2009. The First
Few Hundred (FF100) project ran from April-June 2009 gathering information
on early laboratory-confirmed cases across the UK. In total, 392
confirmed cases were followed up. Children were predominantly affected
(median age 15 years, IQR 10-27). Symptoms were mild and similar
to seasonal influenza, with the exception of diarrhoea, which was
reported by 27%. Eleven per cent of all cases had an underlying
medical condition, similar to the general population. The majority
(92%) were treated with antiviral drugs with 12% reporting adverse
effects, mainly nausea and other gastrointestinal complaints. Duration
of illness was significantly shorter when antivirals were given within
48 h of onset (median 5 vs. 9 days, P=0.01). No patients died, although
14 were hospitalized, of whom three required mechanical ventilation.
The FF100 identified key clinical and epidemiological characteristics
of infection with this novel virus in near real-time.

Author-supplied keywords

  • Adolescent; Adult; Age Distribution; Aged; Antivir
  • H1N1 Subtype; Influenza
  • Human
  • Newborn; Influenza A Virus
  • Preschool; Disease Outbreaks
  • diagnosis/drug therapy/epidemiology/virology; Mal
  • epidemiology; Humans; Infant; Infant
  • statistics /&/ numerical data; Female; Great Brit
  • therapeutic use; Child; Child
  • therapeutic use; Risk Factors; Sex Characteristic

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • E McLean

  • R G Pebody

  • C Campbell

  • M Chamberland

  • C Hawkins

  • J S Nguyen-Van-Tam

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free