Parental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group

  • Shu X
  • Perentesis J
  • Wen W
 et al. 
  • 3

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Abstract

Ras proto-oncogene mutations have been implicated in the pathogenesis of many malignancies, including leukemia. While both human and animal studies have linked several chemical carcinogens to specific ras mutations, little data exist regarding the association of ras mutations with parental exposures and risk of childhood leukemia. Using data from a large case-control study of childhood acute lymphoblastic leukemia (ALL; age

Author-supplied keywords

  • Adolescent
  • Alleles
  • Amphetamines/*toxicity
  • Bone Marrow Examination
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Cocaine/toxicity
  • Female
  • Genes, ras/*drug effects/genetics
  • Humans
  • Hydrocarbons/*toxicity
  • Infant
  • Interviews
  • Leukemia, Lymphocytic, Acute/*chemically induced/*
  • Logistic Models
  • Male
  • Maternal Exposure/*adverse effects
  • Mutation
  • Paternal Exposure/*adverse effects
  • Polymerase Chain Reaction
  • Pregnancy
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Risk Factors

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Authors

  • X O Shu

  • J P Perentesis

  • W Wen

  • J D Buckley

  • E Boyle

  • J A Ross

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