The pathogenesis of pseudotumor cerebri: A mathematical analysis

  • Aisenberg R
  • Rottenberg D
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Abstract

Although the clinical and laboratory features of pseudotumor cerebri have been clearly delineated, the pathogenesis of idiopathic pseudotumor remains a mystery. A number of pathogenetic mechanisms have been proposed to account for some or all of the observed cases. We describe a model relating changes in CSF outflow resistance and/or dural sinus venous pressure to observed changes in (i) CSF pressure, (ii) cerebral blood volume and (iii) the volume and hydrodynamic flow resistance of the ventriculosubarachnoid space. © 1980, All rights reserved.

Author-supplied keywords

  • CBV
  • CSF
  • CSFP
  • ICP
  • If
  • PVI
  • Pd
  • R1s
  • Ra
  • Rs
  • Rt
  • SVP
  • arachnoid villous flow resistance
  • cerebral blood volume
  • cerebrospinal fluid
  • cerebrospinal fluid pressure
  • dural sinus venous pressure
  • flow resistance of the convexity subarachnoid space
  • intracranial pressure
  • limiting value of Rs
  • pressure-volume index
  • rate of CSF formation
  • subarachnoid venous pressure
  • total CSF outflow resistance

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Authors

  • Robert M. Aisenberg

  • David A. Rottenberg

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