Patients with influenza A (H1N1)pdm09 admitted to the ICU. Impact of the recommendations of the SEMICYUC

Abstract

Objectives: To evaluate the impact of the recommendations of the SEMICYUC (2012) on severe influenza A. Design: A prospective multicenter observational study was carried out. Setting: ICU. Patients: Patients infected with severe influenza A (H1N1) from the GETGAG/SEMICYUC registry. Interventions: Analysis of 2 groups according to the epidemic period of the diagnosis (2009-2011; 2013-2015). Variables: Demographic, temporal, comorbidities, severity, treatments, mortality, late diagnosis and place of acquisition. Results: A total of 2,205 patients were included, 1,337 (60.6%) in the first period and 868 (39.4%) in the second one. Age and severity on admission were significantly greater in the second period, as well as co-infection. With regard to the impact of the recommendations, in the second period the diagnosis was established earlier (70.8 vs. 61.1%, P