Journal article

Peanut allergy: Clinical and immunologic differences among patients from 3 different geographic regions.

Vereda A, van Hage M, Ahlstedt S, Ibanez M, Cuesta-Herranz J, van Odijk J, Wickman M, Sampson H ...see all

The Journal of allergy and clinical immunology, vol. 127, issue 3 (2011) pp. 603-607

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Abstract

BACKGROUND: Peanut allergy affects persons from various geographic regions where populations are exposed to different dietary habits and environmental pollens. OBJECTIVE: We sought to describe the clinical and immunologic characteristics of patients with peanut allergy from 3 countries (Spain, the United States, and Sweden) using a molecular component diagnostic approach. METHODS: Patients with peanut allergy from Madrid (Spain, n = 50), New York (United States, n = 30), Gothenburg, and Stockholm (both Sweden, n = 35) were enrolled. Clinical data were obtained either from a specific questionnaire or gathered from chart reviews. IgE antibodies to peanut extract and the peanut allergens rAra h 1, 2, 3, 8 and 9, as well as to cross-reactive birch (rBet v 1) and grass (rPhl p 1, 5, 7, and 12) pollen allergens, were analyzed. RESULTS: American patients frequently had IgE antibodies to rAra h 1 to 3 (56.7% to 90.0%) and often presented with severe symptoms. Spanish patients recognized these 3 recombinant peanut allergens less frequently (16.0% to 42.0%), were more often sensitized to the lipid transfer protein rAra h 9 (60.0%), and typically had peanut allergy after becoming allergic to other plant-derived foods. Swedish patients detected rAra h 1 to 3 more frequently than Spanish patients (37.1% to 74.3%) and had the highest sensitization rate to the Bet v 1 homologue rAra h 8 (65.7%), as well as to rBet v 1 (82.9%). Spanish and Swedish patients became allergic to peanut at 2 years or later, whereas the American children became allergic around 1 year of age. CONCLUSIONS: Peanut allergy has different clinical and immunologic patterns in different areas of the world. Allergen component diagnostics might help us to better understand this complex entity.

Author-supplied keywords

  • Adolescent
  • Age of Onset
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Peanut Hypersensitivity
  • Spain
  • Surveys and Questionnaires
  • Sweden
  • United States
  • diagnosis
  • epidemiology
  • immunology

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Authors

  • Andrea Vereda

  • Marianne van Hage

  • Staffan Ahlstedt

  • Maria Dolores Ibanez

  • Javier Cuesta-Herranz

  • Jenny van Odijk

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