Pharmaceutical crystallization

Abstract

Crystallization is crucial in the pharmaceutical industry as a separation process for intermediates and as the final step in the manufacture of active pharmaceutical ingredients (APIs). In this perspective article to celebrate 10 years of Crystal Growth & Design, we focus on three areas related to crystallization in the pharmaceutical industry: (1) advances in our understanding of the fundamentals of nucleation, (2) production and scale-up of novel solid forms, and (3) continuous processing. While the areas discussed are not new, they are areas, in our opinion, of significant current interest to the community engaged in crystallization in the pharmaceutical industry.(Figure Presented) © 2011 American Chemical Society.