Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients

  • Hu M
  • Lui S
  • Mak V
 et al. 
  • 22


    Mendeley users who have this article in their library.
  • 29


    Citations of this article.


Lipid changes with statin treatments vary greatly between individuals for reasons which are largely unknown. This study was performed to examine the genetic determinants of lipid responses to rosuvastatin in Chinese patients. A total of 125 polymorphisms in 61 candidate genes from 386 Chinese patients were analyzed for association with the lipid responses to rosuvastatin 10 mg daily. The polymorphisms most highly associated with the low-density lipoprotein cholesterol (LDL-C) response were 421C>A in the ATP-binding cassette G2 gene (P=9.2×10), followed by 18281G>A (V257M) in the flavin-containing monooxygenase 3 gene (P=0.0002), 1421C>G in the lipoprotein lipase gene (P=0.002), and rs4420638 in the apolipoprotein E/C-I/C-IV/C-II gene cluster (P=0.004). Patients with familial hypercholesterolemia had 2.6% smaller reductions in LDL-C compared with patients without familial hypercholesterolemia. This study identified some genetic determinants of LDL-C response to rosuvastatin in Chinese patients, which need to be replicated in other populations.

Author-supplied keywords

  • lipid responses
  • pharmacogenetics
  • rosuvastatin
  • single nucleotide polymorphisms

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Miao Hu

  • Sandra S.H. Lui

  • Valiant W.L. Mak

  • Tanya T.W. Chu

  • Vivian W.Y. Lee

  • Emily W.M. Poon

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free