Pharmacogenetics of dopamine receptors and response to antipsychotic drugs in schizophrenia--an update.

  • Scharfetter J
  • 10

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

A considerable number of pharmacogenetic studies have been performed in recent years to define the association of antipsychotic medication response with dopamine receptor polymorphisms and, despite contradictory results, decisive trends have emerged. For the dopamine D2 receptor (DRD2), a trend toward an association with favorable response seems to emerge for the -141C Ins allele of the DRD2 -141C Ins/Del polymorphism and the A1 allele of the Taq1A polymorphism. In the case of the D3 receptor, the Ser9Gly polymorphism has been extensively investigated and a pattern of association is seen between the Ser9 allele and a response to typical antipsychotics, and between the Gly9 allele and a response to atypical antipsychotics. For the D4 receptor, no convincing association results have been reported to date. These trends are discussed with regard to methodological directives and functional implications.

Author-supplied keywords

  • Antipsychotic Agents
  • Antipsychotic Agents: therapeutic use
  • Clinical Trials as Topic
  • Humans
  • Pharmacogenetics
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • Receptors, Dopamine D2: genetics
  • Receptors, Dopamine D2: metabolism
  • Receptors, Dopamine D3
  • Receptors, Dopamine D4
  • Receptors, Dopamine: genetics
  • Receptors, Dopamine: metabolism
  • Schizophrenia
  • Schizophrenia: drug therapy
  • Schizophrenia: genetics

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Authors

  • Joachim Scharfetter

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free