Pharmacokinetic and pharmacodynamic interactions between opioids and propofol

  • Vuyk J
  • 30


    Mendeley users who have this article in their library.
  • 88


    Citations of this article.


The pharmacokinetic and pharmacodynamic interactions between opioids and propofol increasingly have been described and used in clinical practice. It is now known that propofol inhibits both alfentanil and sufentanil metabolism, thereby increasing the plasma concentrations of these opioids, while alfentanil also elevates propofol concentrations. Pharmacodynamically the interaction between propofol and the opioids is generally found to be synergistic. From the interaction data, the optimal propofol concentrations have been extracted that assure adequate anesthesia and the most rapid recovery possible. In the presence of fentanyl, sufentanil, and alfentanil, the optimal propofol concentration is approximately 3.5 μg/ml, whereas in the presence of remifentanil, lower propofol concentrations of 2.5 to 3 μg/ml are required.

Author-supplied keywords

  • Opioids: pharmacodynamics of, pharmacokinetics of
  • Propofol

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Jaap Vuyk

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free