Pharmacokinetics of desmopressin administrated as an oral lyophilisate dosage form in children with primary nocturnal enuresis and healthy adults

  • Østerberg O
  • Savic R
  • Karlsson M
 et al. 
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Abstract

The population pharmacokinetics of desmopressin in children with nocturnal enuresis and in healthy adults were compared using a 1-compartment model with first-order absorption and first-order elimination. In addition, the model consisted of a number of transit compartments before absorption to describe a lag-time. The model gave an adequate description of adult as well as children data and provided a statistically significant better fit to data than a standard lag-time model. The main difference in the pharmacokinetics between children and adults was the absorption delay. The pharmacokinetic difference was minor and presumably of no clinical relevance.

Author-supplied keywords

  • Desmopressin
  • Modeling
  • Pharmacokinetics
  • Primary nocturnal enuresis
  • Transit absorption model

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Authors

  • johan vande walleUniversiteit Gent Faculteit Geneeskunde en Gezondheidswetenschappen

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  • Ole Østerberg

  • Radojka M. Savic

  • Mats O. Karlsson

  • Ulrika S.H. Simonsson

  • Jens Peter Nørgaard

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