The population pharmacokinetics of desmopressin in children with nocturnal enuresis and in healthy adults were compared using a 1-compartment model with first-order absorption and first-order elimination. In addition, the model consisted of a number of transit compartments before absorption to describe a lag-time. The model gave an adequate description of adult as well as children data and provided a statistically significant better fit to data than a standard lag-time model. The main difference in the pharmacokinetics between children and adults was the absorption delay. The pharmacokinetic difference was minor and presumably of no clinical relevance. ©2006 the American College of Clinical Pharmacology.
CITATION STYLE
Østerberg, O., Savic, R. M., Karlsson, M. O., Simonsson, U. S. H., Nørgaard, J. P., Walle, J. V., & Agersø, H. (2006). Pharmacokinetics of desmopressin administrated as an oral lyophilisate dosage form in children with primary nocturnal enuresis and healthy adults. Journal of Clinical Pharmacology, 46(10), 1204–1211. https://doi.org/10.1177/0091270006291838
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