Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203

  • Sun W
  • Powell M
  • O'Dwyer P
 et al. 
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Abstract

The combination of sorafenib with chemotherapy is well-tolerated and is associated with encouraging response rates in several malignances. Both docetaxel and cisplatin are active in gastric cancer. A phase II study was conducted to determine the efficacy and toxicity of combined sorafenib, docetaxel, and cisplatin in patients with metastatic or advanced adenocarcinoma of stomach or gastroesophageal junction (GEJ).

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Authors

  • Weijing Sun

  • Mark Powell

  • Peter J. O'Dwyer

  • Paul Catalano

  • Rafat H. Ansari

  • Al B. Benson

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