Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia

  • Knauf W
  • Lissichkov T
  • Aldaoud A
 et al. 
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Abstract

PURPOSE: This randomized, open-label, parallel-group, multicenter study was designed to compare the efficacy and safety of bendamustine and chlorambucil in previously untreated patients with advanced (Binet stage B or C) chronic lymphocytic leukemia (CLL). PATIENTS AND METHODS: Patients (

Author-supplied keywords

  • Adult
  • Aged
  • Antineoplastic Agents/adverse effects/therapeutic
  • Chlorambucil/adverse effects/therapeutic use
  • Disease-Free Survival
  • Female
  • Fever/chemically induced
  • Follow-Up Studies
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell/drug therap
  • Male
  • Middle Aged
  • Nausea/chemically induced
  • Neutropenia/chemically induced
  • Nitrogen Mustard Compounds/adverse effects/therape
  • Thrombocytopenia/chemically induced
  • Time Factors
  • Treatment Outcome

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Authors

  • W U Knauf

  • T Lissichkov

  • A Aldaoud

  • A Liberati

  • J Loscertales

  • R Herbrecht

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