Phase-sensitive multichannel detection system for chemical and biosensor arrays and fluorescence lifetime-based imaging

  • Rabinovich E
  • O'Brien M
  • Brueck S
 et al. 
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Fluorescence lifetime-based sensors are attractive candidates to satisfy the demand for chemical detection and monitoring in medical, pharmaceutical, and environmental applications. In many cases it is desirable not only to monitor one particular chemical or biological species, but several simultaneously. In this work, we have focused our efforts on the development of a detection platform for multianalyte sensor arrays that is able to monitor changes in the fluorescence lifetimes corresponding to the presence of many analytes of interest in real time. We describe a new version of the multichannel, phase-sensitive electronic detection system employing a multianode photomultiplier tube, light emitting diodes, laser diodes, custom-built detection electronics, and a software package. This system utilizes the frequency-domain method of time-resolved spectroscopy. The present 16-channel prototype of the device is compact and assembled from inexpensive, off-shelf components. Future detection systems may be expec...

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